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See the story behind Verzenio, a treatment option for HR+, HER2– metastatic breast cancer

Every Day Matters

For women living with HR+, HER2– metastatic breast cancer, every day matters. Learn about an everyday CDK4 & 6 inhibitor for a relentless disease.

Verzenio is taken every day, twice a day.
150 mg or 200 mg orally twice a day, as directed by your doctor.

The Relentless Story

Every story starts with an inspiration. The Verzenio story started years ago when it was first envisioned in a laboratory, inspired by women with metastatic breast cancer, and a mission to help them. They are at the heart of everything we do.

See the story behind the first everyday, twice-a-day CDK4 & 6 inhibitor for HR+, HER2– metastatic breast cancer, which was inspired by the relentless women living with this disease.

Learn more about Verzenio as a treatment option for HR+, HER2– metastatic breast cancer

Purpose and Safety Summary
Important Facts About Verzenio® (ver-ZEN-ee-oh). It is also known as abemaciclib.

Verzenio is a prescription medicine used to treat a type of breast cancer. It is a medicine you can take if:

  • You have a type of breast cancer called HR+/HER2– (hormone receptor positive/human epidermal growth factor receptor 2–negative) and the cancer has spread to other parts of the body (metastasized)
  • Verzenio is given along with an aromatase inhibitor as initial endocrine-based therapy for the treatment of postmenopausal women, along with fulvestrant in women whose disease has progressed after hormonal therapy, or by itself in adults whose disease has progressed after hormone therapy and prior chemotherapy

It is not known if Verzenio is safe and effective in children.

Warnings

Verzenio may cause serious side effects, including:

Diarrhea is common with Verzenio, may be severe and may cause dehydration or infection. The most common time to develop diarrhea is during the first month of Verzenio treatment. Your doctor may stop your treatment, lower your dose, or tell you to wait to begin your treatment cycle if you have diarrhea.

At the first sign of loose stools, tell your doctor. You may be advised to start taking an antidiarrheal medicine (such as loperamide) and drink more fluids.

Low white blood cell counts (neutropenia) are common with Verzenio and may cause serious infections that can lead to death. Your doctor should check your white blood cell counts before and during treatment. Tell your doctor right away if you have fever or chills.

Verzenio can cause liver problems. Tell your doctor right away if you have any of the following signs or symptoms of liver problems:

  • Feeling very tired
  • Loss of appetite
  • Pain on the upper right side of your stomach area (abdomen)
  • Bleeding or bruising more easily than normal

Verzenio may cause blood clots in your veins or lungs. These may be serious and have led to death. Tell your doctor if you have the following signs and symptoms of a blood clot:

  • Pain or swelling in your arms or legs
  • Fast breathing
  • Shortness of breath
  • Fast heart rate
  • Chest pain

Verzenio can harm your unborn baby. Use effective birth control during treatment and for at least 3 weeks after the last dose of Verzenio and do not breastfeed during treatment with Verzenio and for at least 3 weeks after your last dose. Verzenio may affect the ability of males to father a child.

Common side effects

The most common side effects of Verzenio include:

  • Nausea
  • Abdominal pain
  • Infections
  • Tiredness
  • Low red blood cell counts (anemia)
  • Low white blood cell counts (leukopenia)
  • Decreased appetite
  • Vomiting
  • Headache
  • Low platelet counts (thrombocytopenia)
  • Hair thinning or hair loss (alopecia)

These are not all the possible side effects of Verzenio.

Tell your doctor if you have any side effects. You can report side effects at 1-800-FDA-1088 or www.fda.gov/medwatch.

Before using

Before you use Verzenio, tell your doctor:

  • If you have fever, chills, or other signs of infection
  • Have liver or kidney problems
  • About all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Especially tell your doctor if you take a medicine that contains ketoconazole. Avoid grapefruit products while taking Verzenio. Grapefruit may increase the amount of Verzenio in your blood
How to take
  • Use Verzenio exactly as your doctor tells you
  • Take your doses of Verzenio at about the same time every day
  • If you vomit or miss a dose take your next dose at your regular time. Do not take 2 doses of Verzenio at the same time to make up for the missed dose
  • If you take too much Verzenio, call your doctor or go to the nearest hospital emergency room right away
Learn more

For more information, call 1-800-545-5979.

This summary provides basic information about Verzenio but does not include all information known about this medicine. Read the information that comes with your prescription each time your prescription is filled. This information does not take the place of talking with your doctor. Be sure to talk to your doctor or other healthcare provider about Verzenio and how to take it. Your doctor is the best person to help you decide if Verzenio is right for you.

Verzenio® is a registered trademark owned or licensed by Eli Lilly and Company, its subsidiaries or affiliates.

AL CON BS 19FEB2019

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