Frequently Asked Questions (FAQs)

What is Verzenio?

Verzenio is a prescription medicine used:

  • In combination with fulvestrant to treat women with hormone receptor (HR)–positive, human epidermal growth factor receptor 2 (HER2)–negative advanced breast cancer or breast cancer that has spread to other parts of the body (metastatic), whose disease has progressed after hormonal therapy
  • Alone to treat adults with HR–positive, HER2–negative advanced breast cancer or metastatic breast cancer whose disease has progressed after hormonal therapy and prior chemotherapy

Learn more about Verzenio

Do you offer any support for patients with metastatic breast cancer (MBC)?

We created the Verzenio Continuous Care™ program to give you personalized support and to help you have a positive experience while taking Verzenio. Your Verzenio Continuous Care Team* will serve as your dedicated partner throughout every stage of your treatment.

Through 1-on-1 check-ins, your Verzenio Continuous Care Team can support you by:

  • Navigating you through the insurance process
  • Identifying savings opportunities
  • Helping you understand what to expect with Verzenio
  • Answering questions you may have about Verzenio

3 simple ways to join

Learn more about Verzenio Continuous Care

*The Verzenio Continuous Care Team is not made up of medical professionals. Your doctor is your source for medical advice.

How should I take Verzenio?

Because Verzenio is an oral medication and not an infusion, you can take it in the convenience of your home. This may allow for more flexibility in your daily life. However, you may need to see your doctor for other treatments. You should swallow Verzenio tablets whole. You should not chew, crush, or split them before swallowing, and should never take a tablet that is broken, cracked, or has been damaged in any way.

You can take Verzenio with or without food. Avoid grapefruit and grapefruit products when taking Verzenio. Grapefruit may increase the amount of Verzenio in your blood.

Learn more about taking Verzenio

What should I do if I miss a dose or get sick after taking a dose?

  • If you miss a dose of Verzenio, or get sick after taking a dose, take your next dose at your regular time. Do not take an extra dose of Verzenio to make up for any dose you may have missed
    • For example, if you forget to take your morning dose, then you should only take your regular evening dose rather than doubling it

Learn more about taking Verzenio

What should I avoid while taking Verzenio?

Avoid grapefruit and grapefruit products while taking Verzenio. Grapefruit may increase the amount of Verzenio in your blood.

Avoid taking ketoconazole during treatment with Verzenio. Tell your healthcare provider if you take medicine that contains ketoconazole.

Learn more about taking Verzenio

What is the dosing schedule for Verzenio + fulvestrant?

Dosing

  • The recommended dose for Verzenio in combination with fulvestrant is 150 mg by mouth twice a day, taken once in the morning and once at night
  • moon and sun 150-mg tabletmoon and sun 150-mg tablet
  • You will receive 4 individual packs, each one containing your dose of 150-mg tablets for 7 days. Each of these packs includes 14 individual 150-mg tablets

No matter what dose is prescribed, you will take 1 tablet, 2 times a day.

If your doctor prescribes:

  • 50-mg tablets, you will receive 4 red packs
  • 100-mg tablets, you will receive 4 green packs
  • 150-mg tablets, you will receive 4 purple packs

Multiple tablet strengths (50 mg, 100 mg, and 150 mg) allow your doctor to make dose adjustments based on your tolerability.

Learn more about dosing with Verzenio + fulvestrant

What is the dosing schedule for Verzenio by itself?

Dosing

  • The recommended dose for Verzenio by itself is 200 mg twice daily by mouth, taken once in the morning and once at night
  • morning and evening 200-mg tabletmorning and evening 200-mg tablet
  • You will receive 4 individual packs, each one containing your dose of 200-mg tablets for 7 days. Each of these packs includes 14 individual 200-mg tablets

No matter what dose is prescribed, you will take 1 tablet, 2 times a day.

If your doctor prescribes:

  • 50-mg tablets, you will receive 4 red packs
  • 100-mg tablets, you will receive 4 green packs
  • 150-mg tablets, you will receive 4 purple packs
  • 200-mg tablets, you will receive 4 light blue packs

Multiple tablet strengths (50 mg, 100 mg, 150 mg, and 200 mg) allow your doctor to make dose adjustments based on your tolerability.

Learn more about dosing with Verzenio by itself

What should I tell my doctor before taking Verzenio?

Tell your doctor if you:
  • Are pregnant or plan to become pregnant. If you become pregnant during your treatment, discuss this with your doctor
  • Are breastfeeding or plan to breastfeed. It is not known if Verzenio passes into your breast milk. Do not breastfeed during treatment with Verzenio and for at least 3 weeks after your last dose. You and your doctor should decide if you will take Verzenio or breastfeed. You should not do both

Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Verzenio and certain other medicines can affect each other, causing serious side effects and may require you to change your dose. Especially tell your doctor if you take a medicine that contains ketoconazole. Avoid grapefruit products while taking Verzenio. Grapefruit may increase the amount of Verzenio in your blood.

Learn more about taking Verzenio

Does Verzenio require tests or monitoring?

Some patients experienced low white blood cell counts (neutropenia) and/or liver problems.

Your doctor will do blood tests to monitor your blood cell counts and to check for liver problems before and during treatment.

Learn more about addressing side effects with Verzenio + fulvestrant or Verzenio by itself

What side effects may I experience while taking Verzenio + fulvestrant?

Verzenio taken with fulvestrant may cause serious side effects, some of which may be severe, including:

Diarrhea. Diarrhea is common with Verzenio and may sometimes be severe. Diarrhea may cause you to develop dehydration or infection. The most common time to develop diarrhea is during the first month of Verzenio treatment. Your doctor may stop your treatment, lower your dose, or tell you to wait to begin your treatment cycle if you have diarrhea.

  • At the first sign of loose stools, tell your doctor. You may be advised to start taking an antidiarrheal medicine (such as loperamide) and drink more fluids

Low white blood cell counts (neutropenia). Low white blood cell counts are common when taking Verzenio and may cause serious infections that can lead to death. Your doctor should check your white blood cell counts before and during treatment.

If you develop low white blood cell counts during treatment with Verzenio, your doctor may stop your treatment, decrease your dose, or may tell you to wait to begin your treatment cycle. Tell your doctor right away if you have signs and symptoms of low white blood cell counts or infections, such as fever and chills.

Liver problems. Your doctor should do blood tests before and during treatment to check your liver. Your doctor may stop your treatment, decrease your dose, or may tell you to wait to begin your treatment cycle if you develop liver problems. Tell your doctor right away if you have any of the following:

  • Feeling very tired
  • Pain on the upper right side of your stomach area (abdomen)
  • Loss of appetite
  • Bleeding or bruising more easily than normal

Blood clots in your veins or in the arteries of your lungs. Verzenio may cause serious blood clots that have led to death. Talk to your doctor if you have the following signs and symptoms of a blood clot:

  • Pain or swelling in your arms or legs
  • Shortness of breath
  • Chest pain
  • Fast breathing
  • Fast heart rate

Most common side effects

These are the most common side effects patients experience on Verzenio + fulvestrant.

  • Diarrhea
  • Nausea
  • Infections
  • Low white blood cell count (leukopenia/neutropenia)
  • Abdominal pain
  • Low red blood cell count (anemia)
  • Tiredness
  • Decreased appetite
  • Vomiting
  • Headache

Tell your doctor if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of Verzenio. For more information, ask your doctor or pharmacist.

Call your doctor for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

You may also report side effects to Eli Lilly and Company at 1-800-545-5979.

Learn more about addressing side effects with Verzenio + fulvestrant

What side effects may I experience while taking Verzenio by itself?

Verzenio taken by itself may cause serious side effects some of which may be severe, including:

Diarrhea. Diarrhea is common with Verzenio and may sometimes be severe. Diarrhea may cause you to develop dehydration or infection. The most common time to develop diarrhea is during the first month of Verzenio treatment. Your doctor may stop your treatment, lower your dose, or tell you to wait to begin your treatment cycle if you have diarrhea.

  • At the first sign of loose stools, tell your doctor. You may be advised to start taking an antidiarrheal medicine (such as loperamide) and drink more fluids

Low white blood cell counts (neutropenia). Low white blood cell counts are common when taking Verzenio and may cause serious infections that can lead to death. Your doctor should check your white blood cell counts before and during treatment.

If you develop low white blood cell counts during treatment with Verzenio, your doctor may stop your treatment, decrease your dose, or may tell you to wait to begin your treatment cycle. Tell your doctor right away if you have signs and symptoms of low white blood cell counts or infections, such as fever and chills.

Liver problems. Your doctor should do blood tests before and during treatment to check your liver. Your doctor may stop your treatment, decrease your dose, or may tell you to wait to begin your treatment cycle if you develop liver problems. Tell your doctor right away if you have any of the following:

  • Feeling very tired
  • Pain on the upper right side of your stomach area (abdomen)
  • Loss of appetite
  • Bleeding or bruising more easily than normal

Blood clots in your veins or in the arteries of your lungs. Verzenio may cause serious blood clots that have led to death. Talk to your doctor if you have the following signs and symptoms of a blood clot:

  • Pain or swelling in your arms or legs
  • Shortness of breath
  • Chest pain
  • Fast breathing
  • Fast heart rate

Most common side effects

These are the most common side effects patients experience on Verzenio:

  • Diarrhea
  • Tiredness
  • Nausea
  • Decreased appetite
  • Abdominal pain
  • Low white blood cell count (neutropenia)
  • Vomiting
  • Infections
  • Low red blood cell count (anemia)
  • Headache
  • Low platelet count (thrombocytopenia)

Tell your doctor if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of Verzenio. For more information, ask your doctor or pharmacist.

Call your doctor for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

You may also report side effects to Eli Lilly and Company at 1-800-545-5979.

Learn more about addressing side effects with Verzenio

Is there any financial assistance available to help cover the cost of Verzenio?

For information about paying for your Verzenio or to download a Savings Card, call 1-844-VERZENIO (1-844-837-9364) or visit our savings page.

Learn more about saving on Verzenio

Is there anything I could have done to prevent metastatic breast cancer?

No. Unfortunately, breast cancer can spread even if you follow advice about prevention and/or have treatment.

Learn more about local MBC advocacy groups and conferences

Will my hair fall out with Verzenio?

84% of women taking Verzenio + fulvestrant and 88% of women taking Verzenio by itself did not experience hair loss or hair thinning.*

*In a clinical trial of 669 patients for Verzenio + fulvestrant, and in a clinical trial of 132 patients for Verzenio by itself.

Learn more about addressing side effects with Verzenio + fulvestrant or Verzenio by itself

How do I open and close the blister pack my medication comes in?

blister pack

Follow the numbered instructions on the blister pack.

  • Step 1: Lift the top flap of the card
  • Step 2: Press and hold down the button on the left
  • Step 3: While holding down the button, pull out the blister pack from the right
  • Step 4: Reinsert blister pack by pushing in until it locks into the sleeves, and close the top flap

Learn more about taking Verzenio

Indication

Verzenio is a prescription medicine used:

  • In combination with fulvestrant to treat women with hormone receptor (HR)–positive, human epidermal growth factor receptor 2 (HER2)–negative advanced breast cancer or breast cancer that has spread to other parts of the body (metastatic), whose disease has progressed after hormonal therapy
  • Alone to treat adults with HR–positive, HER2–negative advanced breast cancer or metastatic breast cancer whose disease has progressed after hormonal therapy and prior chemotherapy

Important Safety Information

Verzenio may cause serious side effects, including:

Diarrhea. Diarrhea is common with Verzenio and may sometimes be severe. Diarrhea may cause you to develop dehydration or infection. The most common time to develop diarrhea is during the first month of Verzenio treatment. Your doctor may stop your treatment, lower your dose, or tell you to wait to begin your treatment cycle if you have diarrhea.

  • At the first sign of loose stools, tell your doctor. You may be advised to start taking an antidiarrheal medicine (such as loperamide) and drink more fluids

Low white blood cell counts (neutropenia). Low white blood cell counts are common when taking Verzenio and may cause serious infections that can lead to death. Your doctor should check your white blood cell counts before and during treatment.

If you develop low white blood cell counts during treatment with Verzenio, your doctor may stop your treatment, decrease your dose, or may tell you to wait to begin your treatment cycle. Tell your doctor right away if you have signs and symptoms of low white blood cell counts or infections, such as fever and chills.

Liver problems. Your doctor should do blood tests before and during treatment to check your liver. Your doctor may stop your treatment, decrease your dose, or may tell you to wait to begin your treatment cycle if you develop liver problems. Tell your doctor right away if you have any of the following:

  • Feeling very tired
  • Pain on the upper right side of your stomach area (abdomen)
  • Loss of appetite
  • Bleeding or bruising more easily than normal

Blood clots in your veins or in the arteries of your lungs. Verzenio may cause serious blood clots that have led to death. Talk to your doctor if you have the following signs and symptoms of a blood clot:

  • Pain or swelling in your arms or legs
  • Shortness of breath
  • Chest pain
  • Fast breathing
  • Fast heart rate

Verzenio can harm your unborn baby. If you are able to become pregnant, you should use effective birth control during treatment with Verzenio and for at least 3 weeks after the last dose of Verzenio. Verzenio may affect the ability of males to father a child.

What are the possible side effects of Verzenio?

The most common side effects of Verzenio include: nausea, infections, decreased appetite, headache, abdominal pain, tiredness and vomiting.

The most common changes to blood tests were low red blood cell count (anemia), low white blood cell counts (leukopenia) and low platelet count (thrombocytopenia).

You are encouraged to report negative side effects of prescription drugs to the Food and Drug Administration (FDA). Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

What should I tell my doctor before taking Verzenio?

Tell your doctor if you:

  • are pregnant or plan to become pregnant. If you become pregnant during your treatment, discuss this with your doctor.
  • are breastfeeding or plan to breastfeed. It is not known if Verzenio passes into your breast milk. Do not breastfeed during treatment with Verzenio and for at least 3 weeks after your last dose. You and your doctor should decide if you will take Verzenio or breastfeed. You should not do both.

Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Verzenio and certain other medicines can affect each other, causing serious side effects and may require you to change your dose. Especially tell your doctor if you take a medicine that contains ketoconazole. Avoid grapefruit products while taking Verzenio. Grapefruit may increase the amount of Verzenio in your blood.

Verzenio is available by prescription only.

Please see Safety Summary for Verzenio.

AL DTC ISI 02OCT2017