Taking Verzenio by itself


The recommended dose for Verzenio by itself is 200 mg twice daily, taken once in the morning and once at night.

200-mg tablet by mouth in the morning
200-mg tablet by mouth in the evening

You will receive 4 individual packs, each one containing your dose of 200-mg tablets for 7 days.

  • Multiple tablet strengths (50 mg, 100 mg, 150 mg, and 200 mg) allow your doctor to make dose adjustments based on your tolerability
  • If you need to reduce your dose due to tolerability, Verzenio is approved to be dosed as low as 50 mg twice daily, as directed by your doctor
  • No matter what dose you are prescribed, you will take 1 tablet, 2 times a day, unless your doctor tells you otherwise


If your doctor prescribes:

50-mg dose Verzenio
100-mg dose Verzenio
150-mg dose Verzenio
Verzenio 200mg dose

AM/PM

Take Verzenio 2 times a day

Take each dose of Verzenio by mouth 2 times a day—once in the morning and once in the evening, unless your doctor tells you otherwise.

Same time every day

Take Verzenio at the same times each day

Try to establish a routine of taking your morning and evening doses at about the same times each day—for example, when you brush your teeth in the morning and before bed.

As directed by your doctor

Follow your doctor’s instructions when taking Verzenio

Take Verzenio exactly as your doctor tells you. Your doctor may change your dose if needed. Do not stop taking Verzenio or change the dose without talking to your doctor.

  • If you miss a dose of Verzenio, or get sick after taking a dose, take your next dose at your regular time. Do not take an extra dose of Verzenio to make up for any dose you may have missed
  • For example, if you forget to take your morning dose, then you should only take your regular evening dose rather than doubling it


If you take more Verzenio than was prescribed, call your doctor or go to the nearest hospital emergency room right away

  • Swallow the prescribed number of Verzenio tablets whole. Do not chew, crush, or split before swallowing
  • You can take Verzenio with or without food
  • Avoid grapefruit and grapefruit products while taking Verzenio. Grapefruit may increase the amount of Verzenio in your blood

  • Verzenio and certain other medicines can affect each other, causing serious side effects or changing the effect of Verzenio or other medications
  • Before starting any medication, make sure you talk to your doctor about all your other medications. Some examples include prescription and over-the-counter medicines, vitamins, and herbal supplements. Your doctor may need to change your dose

If you have questions about Verzenio, or need more information on how to take it, you should talk to your doctor. You can also call us at 1-844-VERZENIO (1-844-837-9364) or sign up for our Verzenio Continuous Care™ Support Program.

Purpose and Safety Summary
Important Facts About Verzenio® (ver-ZEN-ee-oh). It is also known as abemaciclib.

Verzenio is a prescription medicine used to treat a type of breast cancer. It is a medicine you can take if:

  • You have a type of breast cancer called HR+/HER2– (hormone receptor positive/human epidermal growth factor receptor 2–negative) and the cancer has spread to other parts of the body (metastasized)
  • Verzenio is given along with an aromatase inhibitor as initial endocrine-based therapy for the treatment of postmenopausal women, along with fulvestrant in women whose disease has progressed after hormonal therapy, or by itself in adults whose disease has progressed after hormone therapy and prior chemotherapy

It is not known if Verzenio is safe and effective in children.

Warnings

Verzenio may cause serious side effects, including:

Diarrhea is common with Verzenio, may be severe and may cause dehydration or infection. The most common time to develop diarrhea is during the first month of Verzenio treatment. Your doctor may stop your treatment, lower your dose, or tell you to wait to begin your treatment cycle if you have diarrhea.

At the first sign of loose stools, tell your doctor. You may be advised to start taking an antidiarrheal medicine (such as loperamide) and drink more fluids.

Low white blood cell counts (neutropenia) are common with Verzenio and may cause serious infections that can lead to death. Your doctor should check your white blood cell counts before and during treatment. Tell your doctor right away if you have fever or chills.

Verzenio may cause severe or life-threatening inflammation (swelling) of the lungs during treatment that can lead to death. Tell your healthcare provider right away if you have any new or worsening symptoms, including:

  • trouble breathing or shortness of breath
  • cough with or without mucus
  • chest pain

Verzenio can cause liver problems. Tell your doctor right away if you have any of the following signs or symptoms of liver problems:

  • Feeling very tired
  • Loss of appetite
  • Pain on the upper right side of your stomach area (abdomen)
  • Bleeding or bruising more easily than normal

Verzenio may cause blood clots in your veins or lungs. These may be serious and have led to death. Tell your doctor if you have the following signs and symptoms of a blood clot:

  • Pain or swelling in your arms or legs
  • Fast breathing
  • Shortness of breath
  • Fast heart rate
  • Chest pain

Verzenio can harm your unborn baby. Use effective birth control during treatment and for at least 3 weeks after the last dose of Verzenio and do not breastfeed during treatment with Verzenio and for at least 3 weeks after your last dose. Verzenio may affect the ability of males to father a child.

Common side effects

The most common side effects of Verzenio include:

  • Nausea
  • Abdominal pain
  • Infections
  • Tiredness
  • Low red blood cell counts (anemia)
  • Low white blood cell counts (leukopenia)
  • Decreased appetite
  • Vomiting
  • Headache
  • Low platelet counts (thrombocytopenia)
  • Hair thinning or hair loss (alopecia)

These are not all the possible side effects of Verzenio.

Tell your doctor if you have any side effects. You can report side effects at 1-800-FDA-1088 or www.fda.gov/medwatch.

Before using

Before you use Verzenio, tell your doctor:

  • If you have fever, chills, or other signs of infection
  • Have liver or kidney problems
  • About all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Especially tell your doctor if you take a medicine that contains ketoconazole. Avoid grapefruit products while taking Verzenio. Grapefruit may increase the amount of Verzenio in your blood
How to take
  • Use Verzenio exactly as your doctor tells you
  • Take your doses of Verzenio at about the same time every day
  • If you vomit or miss a dose take your next dose at your regular time. Do not take 2 doses of Verzenio at the same time to make up for the missed dose
  • If you take too much Verzenio, call your doctor or go to the nearest hospital emergency room right away
Learn more

For more information, call 1-800-545-5979.

This summary provides basic information about Verzenio but does not include all information known about this medicine. Read the information that comes with your prescription each time your prescription is filled. This information does not take the place of talking with your doctor. Be sure to talk to your doctor or other healthcare provider about Verzenio and how to take it. Your doctor is the best person to help you decide if Verzenio is right for you.

Verzenio® is a registered trademark owned or licensed by Eli Lilly and Company, its subsidiaries or affiliates.

AL CON BS 20SEP2019