Side effects with Verzenio + fulvestrant
Most common side effects
- Diarrhea
- Nausea
- Infections
- Low white blood cell count (leukopenia/neutropenia)
- Abdominal pain
- Low red blood cell count (anemia)
- Tiredness
- Decreased appetite
- Vomiting
- Headache
Tell your doctor if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of Verzenio. For more information, ask your doctor or pharmacist.
In a study of Verzenio + fulvestrant, it was common for patients to experience diarrhea that was sometimes severe. In some cases, it led to dehydration or infection. Diarrhea was greatest during the first month, and then decreased.
- The median time to first symptoms was about a week (the median duration of moderate and more significant diarrhea was 9 and 6 days, respectively). However, some patients experienced this earlier or later in therapy
- The diarrhea was managed by their doctor with an anti-diarrhea medicine, like loperamide (sometimes sold under the brand name Imodium®), and/or by reducing the dose.* You should call your doctor right away if your diarrhea does not go away or gets worse
*22% of patients required a dose omission, and 22% required a dose reduction.
Call your doctor for medical advice about side effects. You are encouraged to report side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1‑800‑FDA‑1088.
You may also report side effects to Eli Lilly and Company at 1‑800‑545‑5979.
Will my hair fall out with Verzenio?
- In a study of patients taking Verzenio + fulvestrant, 16% of patients experienced hair thinning or loss
- In a clinical trial of patients with HR+, HER2– metastatic breast cancer, 446 patients who progressed following prior hormone treatments received Verzenio + fulvestrant.