What is Verzenio?

Verzenio is a prescription medicine used:

  • In combination with fulvestrant to treat women with hormone receptor (HR)–positive, human epidermal growth factor receptor 2 (HER2)–negative advanced breast cancer or breast cancer that has spread to other parts of the body (metastatic), whose disease has progressed after hormonal therapy
  • Alone to treat adults with HR–positive, HER2–negative advanced breast cancer or metastatic breast cancer whose disease has progressed after hormonal therapy and prior chemotherapy

Verzenio is the first and only tablet of its kind taken every day*

Because Verzenio is an oral medication and not an infusion, you can take it in the convenience of your home. This may allow for more flexibility in your daily life. However, you may need to see your doctor for other treatments.

*150 mg or 200 mg twice a day, as directed by your doctor.

How often should I take Verzenio?

Verzenio Dose

AM/PM

water glasses

Take each dose of Verzenio by mouth 2 times a day—once in the morning and once in the evening, unless your doctor tells you otherwise.

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Same time every day

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Try to establish a routine of taking your morning and evening doses at about the same times each day.

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As directed by your doctor

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Take Verzenio exactly as your doctor tells you. Your doctor may change your dose if needed. Do not stop taking Verzenio or change the dose without talking to your doctor.

What should I do if I miss a dose or get sick after taking a dose?

  • If you miss a dose of Verzenio, or get sick after taking a dose, take your next dose at your regular time. Do not take an extra dose of Verzenio to make up for any dose you may have missed
    • For example, if you forget to take your morning dose, then you should only take your regular evening dose rather than doubling it

If you take more Verzenio than was prescribed,
call your doctor or go to the nearest hospital emergency room right away

How should I take Verzenio?

  • Swallow the prescribed number of Verzenio tablets whole. Do not chew, crush, or split before swallowing
  • You can take Verzenio with or without food
  • Avoid grapefruit and grapefruit products while taking Verzenio. Grapefruit may increase the amount of Verzenio in your blood

Can other medicines affect Verzenio?

  • Verzenio and certain other medicines can affect each other, causing serious side effects or changing the effect of Verzenio or other medications. Your doctor may need to change your dose
  • Before starting any medication, make sure you talk to your doctor about all your other medications. Some examples include prescription and over-the-counter medicines, vitamins, and herbal supplements

If you have questions about Verzenio, or need more information on how to take it, you should talk to your doctor. You can also call us at 1-844-VERZENIO (1-844-837-9364).

Indication

Verzenio is a prescription medicine used:

  • In combination with fulvestrant to treat women with hormone receptor (HR)–positive, human epidermal growth factor receptor 2 (HER2)–negative advanced breast cancer or breast cancer that has spread to other parts of the body (metastatic), whose disease has progressed after hormonal therapy
  • Alone to treat adults with HR–positive, HER2–negative advanced breast cancer or metastatic breast cancer whose disease has progressed after hormonal therapy and prior chemotherapy

Important Safety Information

Verzenio may cause serious side effects, including:

Diarrhea. Diarrhea is common with Verzenio and may sometimes be severe. Diarrhea may cause you to develop dehydration or infection. The most common time to develop diarrhea is during the first month of Verzenio treatment. Your doctor may stop your treatment, lower your dose, or tell you to wait to begin your treatment cycle if you have diarrhea.

  • At the first sign of loose stools, tell your doctor. You may be advised to start taking an antidiarrheal medicine (such as loperamide) and drink more fluids

Low white blood cell counts (neutropenia). Low white blood cell counts are common when taking Verzenio and may cause serious infections that can lead to death. Your doctor should check your white blood cell counts before and during treatment.

If you develop low white blood cell counts during treatment with Verzenio, your doctor may stop your treatment, decrease your dose, or may tell you to wait to begin your treatment cycle. Tell your doctor right away if you have signs and symptoms of low white blood cell counts or infections, such as fever and chills.

Liver problems. Your doctor should do blood tests before and during treatment to check your liver. Your doctor may stop your treatment, decrease your dose, or may tell you to wait to begin your treatment cycle if you develop liver problems. Tell your doctor right away if you have any of the following:

  • Feeling very tired
  • Pain on the upper right side of your stomach area (abdomen)
  • Loss of appetite
  • Bleeding or bruising more easily than normal

Blood clots in your veins or in the arteries of your lungs. Verzenio may cause serious blood clots that have led to death. Talk to your doctor if you have the following signs and symptoms of a blood clot:

  • Pain or swelling in your arms or legs
  • Shortness of breath
  • Chest pain
  • Fast breathing
  • Fast heart rate

Verzenio can harm your unborn baby. If you are able to become pregnant, you should use effective birth control during treatment with Verzenio and for at least 3 weeks after the last dose of Verzenio. Verzenio may affect the ability of males to father a child.

What are the possible side effects of Verzenio?

The most common side effects of Verzenio include: nausea, infections, decreased appetite, headache, abdominal pain, tiredness and vomiting.

The most common changes to blood tests were low red blood cell count (anemia), low white blood cell counts (leukopenia) and low platelet count (thrombocytopenia).

You are encouraged to report negative side effects of prescription drugs to the Food and Drug Administration (FDA). Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

What should I tell my doctor before taking Verzenio?

Tell your doctor if you:

  • are pregnant or plan to become pregnant. If you become pregnant during your treatment, discuss this with your doctor.
  • are breastfeeding or plan to breastfeed. It is not known if Verzenio passes into your breast milk. Do not breastfeed during treatment with Verzenio and for at least 3 weeks after your last dose. You and your doctor should decide if you will take Verzenio or breastfeed. You should not do both.

Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Verzenio and certain other medicines can affect each other, causing serious side effects and may require you to change your dose. Especially tell your doctor if you take a medicine that contains ketoconazole. Avoid grapefruit products while taking Verzenio. Grapefruit may increase the amount of Verzenio in your blood.

Verzenio is available by prescription only.

Please see Safety Summary for Verzenio.

AL DTC ISI 02OCT2017