Addressing side effects
Overall, the key information to know about diarrhea: it can be managed with the appropriate steps, so EXPECT, PLAN, and ACT.
DIARRHEA IS A COMMON SIDE EFFECT
Diarrhea is a common side effect with Verzenio and may sometimes be severe, but you and your doctor can take steps to manage it. If diarrhea occurs, it will most likely happen in the first week. You should be on the lookout for cramping or frequent, loose, or watery stools.
PLAN AHEAD OF TIME
It is important to plan ahead of time with your doctor. Make sure you have an over-the-counter anti-diarrhea medicine, such as loperamide (also known as Imodium®) available at home before you start taking Verzenio.
IMMEDIATE 24-HOUR ACTION PLAN
If you begin experiencing diarrhea, it is very important that you take action immediately at the first signs of symptoms. The best way to manage diarrhea is to start an anti-diarrheal at the first sign and call your doctor, who may make a dose change.
- STEP 1: Start an anti-diarrheal and call your doctor
- If you are experiencing diarrhea, you need to start taking an anti-diarrheal as directed on the packaging and call your doctor or nurse immediately so they are aware and can help you manage the diarrhea.
- STEP 2: Stay hydrated and drink clear fluids
- Drink at least 8-10 glasses of clear fluids in the first 24 hours you experience symptoms (and continue any day you experience diarrhea) to avoid dehydration.
- STEP 3: Watch for improvement and follow up with your doctor
- Ideally, the anti-diarrheal will be able to help resolve your symptoms, but if symptoms continue after the first 24 hours, you need to talk to your doctor or nurse that day. He or she may consider adjusting your dose, with the ultimate goal of finding which dose is right for you. Verzenio is effective at different doses, so it is important to find what dose is right for your body.
Monitoring blood counts and liver function
Some patients experienced low white blood cell counts (neutropenia) and/or liver problems.
Your doctor will do blood tests to monitor your blood cell counts and to check for liver problems before and during treatment.