If You're Living with HR+/HER2– Metastatic Breast Cancer, More Time Is Possible

Verzenio was studied in a clinical trial of 669 women with HR+, HER2– metastatic breast cancer who progressed following prior hormone treatments. 446 patients were treated with Verzenio plus fulvestrant and 223 were treated with fulvestrant alone. In a clinical study 48.1% of women taking Verzenio + Fulvestrant saw their tumors shrink vs. 21.3% taking fulvestrant alone.

In a clinical study women taking Verzenio + fulvestrant lived for a median of 46.7 months vs 37.3 months on fulvestrant alone. In the same study, Verzenio + fulvestrant delayed disease progression for a median of 16.4 months vs 9.3 months with fulvestrant alone.

Undergoing treatment for metastatic breast cancer is one of the most difficult experiences a woman can take on. But you don't have to do it alone. With the links below, explore the information and resources designed to help support you and aid in your treatment.

Verzenio is the first and only treatment of its kind that can be taken everyday for the treatment of certain types of HR+, HER2– metastatic breast cancer - an everyday, twice daily treatment for a relentless disease.

Ask Your Doctor About Verzenio

Your Best Advocate

You don't need us to tell you that you are worthy of respect, empathy and understanding from your care team. If you feel like you're not being heard or understood during your medical appointments, it's your right to ask direct questions related to your concerns. Remember — it's your body and your care. You deserve answers.

Partnering With Your Doctor

Have the Talk

Despite being diagnosed at a similar rate to White women, Black women are 41% more likely to die from metastatic breast cancer than White women, and are often diagnosed at more advanced stages^*.

That's why its so important to talk to the women in your life to connect with and support you.

More Connections

More Resources

We know how challenging it can be to navigate the medical care system during this critical time, so we've compiled additional information to help support you and aid in your care. Visit hhs.gov for information on patients rights and responsibilities under the Affordable Care Act.

See how you can save on treatment and get support along the way with the Verzenio Continuous Care Program.

More about Verzenio Continuous Care

^* Source: Patterns and Trends in Age-Specific Black-White Differences in Breast Cancer Incidence and Mortality - United States, 1999-2014, CDC 2014

Important Facts About Verzenio^® (ver-ZEN-ee-oh). It is also known as abemaciclib.

Verzenio is a prescription medicine used to treat certain types of breast cancer known as HR+/HER2– (hormone receptor positive/human epidermal growth factor receptor 2 negative) breast cancer.

It is a medicine you can take if:

You have node-positive early breast cancer that has a high risk of coming back as determined by your healthcare provider. Verzenio is given along with hormonal therapy to women and men.
Or, the cancer has spread to other parts of the body (metastasized). If you are postmenopausal, or male, then Verzenio is given with an aromatase inhibitor as initial endocrine-based therapy. If you are a female or male, and the cancer has gotten worse after hormone therapy, then Verzenio is given with fulvestrant. If you are female or male and the cancer has gotten worse after both hormone therapy and chemotherapy, then Verzenio is given by itself.

It is not known if Verzenio is safe and effective in children.

Warnings

Verzenio may cause serious side effects, including:

Diarrhea is common with Verzenio, may sometimes be severe and may cause dehydration or infection. The most common time to develop diarrhea is during the first month of Verzenio treatment. If you develop diarrhea during treatment with Verzenio, your healthcare provider may tell you to temporarily stop taking it, stop your treatment, or decrease your dose.

If you have any loose stools, start taking an antidiarrheal medicine (such as loperamide), drink more fluids, and tell your healthcare provider right away.

Low white blood cell counts (neutropenia) are common with Verzenio and may cause serious infections that can lead to death. Your healthcare provider should check your white blood cell counts before and during treatment. If you develop low white blood cell counts during treatment with Verzenio, your healthcare provider may tell you to temporarily stop taking it, decrease your dose, or wait before starting your next month of treatment. Tell your healthcare provider right away if you have signs and symptoms of low white blood cell counts or infections, such as fever and chills.

Verzenio may cause severe or life-threatening inflammation (swelling) of the lungs during treatment that can lead to death. If you develop lung problems during treatment with Verzenio, your healthcare provider may tell you to temporarily stop taking it, decrease your dose, or stop your treatment. Tell your healthcare provider right away if you have any new or worsening symptoms, including:

Trouble breathing or shortness of breath
Cough with or without mucus
Chest pain

Verzenio can cause serious liver problems. Your healthcare provider should do blood tests to check your liver before and during treatment. If you develop liver problems during treatment with Verzenio, your healthcare provider may reduce your dose or stop your treatment. Tell your healthcare provider right away if you have any of the following signs or symptoms of liver problems:

Feeling very tired
Pain on the upper right side of your stomach area (abdomen)
Loss of appetite
Bleeding or bruising more easily than normal

Verzenio may cause blood clots in your veins, or in the arteries of your lungs. Verzenio may cause serious blood clots that have led to death. If you develop blood clots during treatment with Verzenio, your healthcare provider may tell you to temporarily stop taking it. Tell your healthcare provider right away if you have any of the following signs and symptoms of a blood clot:

Pain or swelling in your arms or legs
Shortness of breath
Chest pain
Fast breathing
Fast heart rate

Verzenio can harm your unborn baby. Use effective birth control (contraception) during treatment and for 3 weeks after the last dose of Verzenio and do not breastfeed during treatment with Verzenio and for at least 3 weeks after your last dose. Verzenio may affect the ability of males to father a child.

Common side effects

The most common side effects of Verzenio include:

Nausea
Infections
Low red blood cell counts (anemia)
Decreased appetite
Headache
Hair thinning or hair loss (alopecia)
Abdominal pain
Tiredness
Low white blood cell counts (leukopenia)
Vomiting
Low platelet counts (thrombocytopenia)

These are not all the possible side effects of Verzenio.

Tell your healthcare provider if you have any side effects. You can report side effects at 1-800-FDA-1088 or www.fda.gov/medwatch.

Before using

Before you use Verzenio, tell your healthcare provider about all your medical conditions, including:

If you have fever, chills, or other signs of infection.
If you have a history of blood clots in your veins.
Have lung or breathing problems.
Have liver or kidney problems.
If you are pregnant, plan to become pregnant, or are breastfeeding.
About all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Especially tell your healthcare provider if you take a medicine that contains ketoconazole.

How to take

Take Verzenio exactly as your healthcare provider tells you.
Your healthcare provider may change your dose if needed. Do not stop taking Verzenio or change the dose without talking to your healthcare provider.
Verzenio may be taken with or without food.
Swallow Verzenio tablets whole. Do not chew, crush, or split the tablets before swallowing. Do not take Verzenio tablets if they are broken, cracked, or damaged.
Take your doses of Verzenio at about the same time every day.
If you vomit or miss a dose of Verzenio, take your next dose at your regular time. Do not take 2 doses at the same time to make up for the missed dose.

What to avoid during treatment

Avoid taking ketoconazole during treatment with Verzenio. Tell your healthcare provider if you take a medicine that contains ketoconazole
Avoid grapefruit and products that contain grapefruit during treatment with Verzenio. Grapefruit may increase the amount of Verzenio in your blood

Learn more

For more information, call 1-800-545-5979 or go to verzenio.com.

This summary provides basic information about Verzenio but does not include all information known about this medicine. Read the information that comes with your prescription each time your prescription is filled. This information does not take the place of talking with your healthcare provider. Be sure to talk to your healthcare provider about Verzenio and how to take it. Your healthcare provider is the best person to help you decide if Verzenio is right for you.

Verzenio^® is a registered trademark owned or licensed by Eli Lilly and Company, its subsidiaries or affiliates.

AL CON BS 14OCT2021