About Verzenio
Whether you’re newly diagnosed or just starting treatment, learn more about Verzenio and how it works.
What is Verzenio?
Verzenio is a targeted treatment known as a CDK4 & 6 inhibitor. Verzenio is a non-chemotherapy oral tablet.
Verzenio is a targeted treatment, known as a CDK4 & 6 inhibitor, used to treat a type of breast cancer. It is a medicine you can take if you have a type of breast cancer called HR+, HER2– (hormone receptor positive/human epidermal growth factor receptor 2 negative) and the cancer has spread to other parts of the body (metastasized).
Verzenio is given in combination with an aromatase inhibitor as initial endocrine-based therapy for the treatment of adults, in combination with fulvestrant in adults whose disease has progressed after hormone therapy, or alone in adults whose disease has progressed after hormone therapy and prior chemotherapy.
It is not known if Verzenio is safe and effective in children.
CDK4 & 6=cyclin-dependent kinases 4 and 6.
How Verzenio works
Verzenio works inside the cell to block CDK4 & 6 activity and help stop the growth of cancer cells, so they may eventually die*
Verzenio is a CDK4 & 6 inhibitor used to treat HR+, HER2– metastatic breast cancer. Verzenio works to block specific proteins called CDK4 & CDK6. CDK4 & 6 proteins help control how fast cells grow. These proteins, along with hormones like estrogen, play an important role in the growth and division process of normal cells.
But if you have HR+, HER2– breast cancer, CDK4 & 6 proteins become overactive, causing the cancer cells to grow and divide uncontrollably, which makes the tumor grow. This can also lead to cancer cells spreading to other parts of the body, which is called metastasis.
Verzenio can be taken alone, but it is usually taken with hormone therapy to slow the growth of cancer cells. Hormone therapy (aromatase inhibitor or fulvestrant) works outside the cell to help cut off estrogen that feeds the cancer. Verzenio works inside the cell to block CDK4 & 6 activity and help stop the growth of cancer cells, so they may eventually die.* When Verzenio inhibits CDK4 & 6 in healthy cells, it can lead to side effects, some of which may be serious.
*Based on pre-clinical studies.
How is Verzenio different?
Verzenio is taken differently—it's the first and only CDK4 & 6 inhibitor that can be taken every day, twice a day†
Verzenio is a CDK4 & 6 inhibitor. It is the first and only oral tablet of its kind that can be taken every day for the treatment of HR+, HER2– metastatic breast cancer.
Because Verzenio is an oral medication and not an infusion, you can take it in the convenience of your home. This may allow for more flexibility in your daily life. However, you may need to see your doctor for other treatments.
†150 mg or 200 mg orally twice a day, as directed by your doctor.
Explore an advancement in the treatment data for HR+, HER2– metastatic breast cancer
SELECT SAFETY INFORMATION
Verzenio may cause serious side effects, including:
Diarrhea is common with Verzenio, may be severe and may cause dehydration or infection. The most common time to develop diarrhea is during the first month of Verzenio treatment. Your doctor may stop your treatment, lower your dose, or tell you to wait to begin your treatment cycle if you have diarrhea.
At the first sign of loose stools, tell your doctor. You may be advised to start taking an antidiarrheal medicine (such as loperamide) and drink more fluids.
Discover stories from Verzenio, a treatment option for certain types of HR+, HER2− metastatic breast cancer
00:00-0:09
[A woman is sitting in her living room, looking at a photo album. Over her shoulder, we see photos of the woman with her husband and daughter. She turns to a page that has “Future Memories” written on it, then flips that page to reveal an image of her and her daughter walking outside on an early winter day. The photo begins to come to life with a flipping motion and the camera zooms into the scene.]
VO Pam: Living with metastatic breast cancer means I cherish my memories. But I don’t just look back on them, I look forward to the chance to make new ones every day, with Verzenio.
00:10-00:14
[The photo continues to come to life with a flipping motion and the scene unfolds. The scene of the woman and her daughter is now full screen. The two are walking along a street, looking at shop windows while smiling.]
AVO: Verzenio is proven to help you live significantly longer when taken with fulvestrant.
Caption: Proven to help women live longer
Caption: Women taking Verzenio + fulvestrant lived for a median of 46.7 months vs 37.3 months on fulvestrant alone.
00:15-00:21
[The two of them stop in front of a shop window and admire a pair of baby overalls hanging in the display. The two enter the shop.]
AVO: Verzenio + fulvestrant is for HR+, HER2− metastatic breast cancer that has progressed after hormone therapy.
Caption: Verzenio + fulvestrant delayed disease progression for a median of 16.4 months vs 9.3 months with fulvestrant alone.
00:22-00:28
[As the woman walks into the shop, she’s now in a baby nursery that’s in the process of being decorated. Her husband is painting the walls and her now-pregnant daughter is taking a mobile out of a cardboard box. The woman admires the mobile.]
AVO: Diarrhea is common, may be severe, or cause dehydration or infection. At the first sign, call your doctor, start an anti-diarrheal, and drink fluids.
Caption: At the first sign of diarrhea, call your doctor, start an anti-diarrheal medication, and drink fluids.
00:29-00:47
[The woman is now holding the mobile and she walks off-screen with her daughter. This reveals a window behind her, where we can see two people walking with a baby stroller. We cut closer to see that this is the woman, her daughter, and her new grandson arriving to a swing in a park. The woman and her daughter bring the baby into the swing and begin pushing him joyfully. As the woman pushes the baby a final time, we transition to a dinner table, where she is pushing the baby, now older, towards the table in his highchair. The scene develops to show a table, full of the woman’s family and friends gathered for dinner.]
AVO: Before taking Verzenio, tell your doctor about any fever, chills, or other signs of infection. Verzenio may cause low white blood cell counts, which may cause serious infection that can lead to death. Life-threatening lung inflammation can occur. Tell your doctor about any new or worsening trouble breathing, cough, or chest pain. Serious liver problems can happen. Symptoms include fatigue, appetite loss, stomach pain, and bleeding or bruising. Blood clots that can lead to death have occurred.
Caption: Common side effects include nausea, infections, low blood cells and platelets, decreased appetite, headache, abdominal pain, tiredness (fatigue), vomiting, and hair thinning or loss.
00:48-00:53
[The woman walks away from her grandson to sit down at the head of the table and take in the scene.]
AVO: Tell your doctor if you have pain or swelling in your arms or legs, shortness of breath, chest pain, and rapid breathing or heart rate, or if you are nursing, pregnant, or plan to be.
Caption: Tell your doctor about all your medical conditions and medications you take and if you are nursing, pregnant, or plan to be pregnant.
00:54-00:56
[The camera pulls back to reveal this scene in the photo album from the beginning. A hand comes in to flip the page, revealing the Verzenio logo on the following page.]
VO Pam: I’m making future memories every day with Verzenio.
Caption: Available by prescription only. 1-844-VERZENIO (1-844-837-9364)
00:57-01:00
[The Verzenio and Lilly logos appear.]
AVO: Ask your doctor about everyday Verzenio.
Caption: Everyday Verzenio® abemaciclib 50 | 100 | 150 | 200 mg tablets twice a day. verzenio.com. For pricing information, please visit lillypricinginfo.com/verzenio or call 1-844-VERZENIO (1-844-837-9364)
Caption: Verzenio® is a registered trademark owned or licensed by Eli Lilly and Company, its subsidiaries or affiliates. PP-AL-US-3130 12/2022 ©Lilly USA, LLC 2022. All rights reserved.
Learn about every day, twice a day Verzenio.
150 mg or 200 mg orally twice a day, as directed by your doctor.
SELECT SAFETY INFORMATION
Verzenio may cause serious side effects, including:
Low white blood cell counts (neutropenia) are common with Verzenio and may cause serious infections that can lead to death. Your doctor should check your white blood cell counts before and during treatment. Tell your doctor right away if you have fever or chills.
Real Relentless Women
Hear from real, relentless women living with metastatic breast cancer. For some, this includes Verzenio and how the treatment has impacted their story.
Jeanelle
Jeanelle is a real Verzenio patient who puts family first. In addition to spending time with her loved ones, Jeanelle finds an outlet through dance. She discusses how her diagnosis of metastatic breast cancer impacted her life and her time on treatment with Verzenio.
Nancy
For Nancy, a real Verzenio patient, being there for her family is everything to her. She talks about her feelings about her diagnosis as well as how treatment with Verzenio has helped her feel more hopeful.
Holly
Holly, a real Verzenio patient, restores a boat with her husband so they can spend their retirement sailing the world. They discuss how metastatic breast cancer and discovering Verzenio has impacted their lives.
Honey
Honey, a grandmother and real Verzenio patient, talks to her lifelong friend about everything they’ve been through, including her diagnosis with metastatic breast cancer.
Teresa
Teresa, a wife, mother, grandmother, and a real Verzenio patient, talks about her experience living with metastatic breast cancer, and her daughter talks about how it has impacted their entire family.
Karen
Karen, a patient advocate living with metastatic breast cancer, talks about empowering women like her around the world. Her sister tells Karen what an inspiration her strength is to her and so many other women.
Learn more about Verzenio as a treatment option for HR+, HER2– metastatic breast cancer